Factors contributing to improved local control after mastectomy in patients with breast cancer aged 40 years or younger

Lammers, Elke J.R.; Huibers, Paulien; van der Sangen, Maurice J.C.; van de Poll-Franse, Lonneke V.; Poortmans, Philip M.P.; Ernst, Miranda F.; Lemaire, Bea M.D.; Meijs, Claartje M.E.M.; Nuytinck, Hans K.S.; Voogd, Adri C.

doi:10.1016/j.breast.2009.10.009

« Previous Next »The Breast
Volume 19, Issue 1 , Pages 44-49, February 2010

Factors contributing to improved local control after mastectomy in patients with breast cancer aged 40 years or younger

Elke J.R. Lammers
- Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
- These authors contributed equally to this work.
Paulien Huibers
- Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
- These authors contributed equally to this work.
Maurice J.C. van der Sangen
- Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands
Lonneke V. van de Poll-Franse
- Eindhoven Cancer Registry, Eindhoven, The Netherlands
- CoRPS – Centre of Research on Psychology in Somatic Diseases, Department of Medical Psychology, Tilburg University, The Netherlands
Philip M.P. Poortmans
- Department of Radiotherapy, Bernard Verbeeten Institute, Tilburg, The Netherlands
Miranda F. Ernst
- Department of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands
Bea M.D. Lemaire
- Department of Surgery, Elkerliek Hospital, Helmond, The Netherlands
Claartje M.E.M. Meijs
- Department of Surgery, St. Elisabeth Hospital, Tilburg, The Netherlands
Hans K.S. Nuytinck
- Department of Surgery, Amphia Hospital, Breda, The Netherlands
Adri C. Voogd
- Department of Epidemiology, Faculty of Health Medicine and Life Sciences, Research Institute Growth and Development (GROW) Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
- Corresponding author. Tel.: +31 43 3882387; fax: +31 43 3884128.

Received 30 June 2009; received in revised form 12 September 2009; accepted 20 October 2009. published online 13 November 2009.

Abstract

Long-term local control rates were studied in a series of 659 patients with invasive breast cancer aged 40 years or younger, who underwent mastectomy in general hospitals in the southern part of the Netherlands between 1988 and 2005. During a median follow-up time of 6.0 years, 34 patients developed a local recurrence in the chest wall without previous or simultaneous evidence of distant disease. The 5- and 10-year actuarial local recurrence rates for the total group were 5.6% (95% confidence interval [95% CI], 3.5–7.7%) and 7.3% (95% CI, 4.7–9.9%), respectively. A multivariate analysis showed that patients receiving radiotherapy (hazards ratio [HR], 0.29; 95% CI, 0.10–0.96) or adjuvant systemic treatment (HR 0.23; 95% CI, 0.08–0.65) had a significantly lower risk of local recurrence. It is concluded that excellent local control rates can be obtained with mastectomy in young women with breast cancer, especially in those who receive adjuvant systemic treatment and/or radiotherapy.

Keywords: Breast carcinoma, Young age, Local control, Mastectomy, Radiotherapy, Systemic treatment