The Breast
Volume 19, Issue 3 , Pages 168-171, June 2010

Hypofractionation in adjuvant breast radiotherapy

Department of Radiation Oncology, UMDNJ-RWJMS, Cancer Institute of New Jersey, 195 Little Albany St., New Brunswick, NJ 08901, USA

Abstract 

Altered fractionation for whole breast irradiation has been extensively studied over the past 20 years, with recent updated publications from several landmark randomized trials. In this review, the radiobiological principles underlying altered fractionation schedules are reviewed, and outcomes, including local control, acute and chronic toxicities from the major published studies are summarized. While the studies published to date provide strong clinical evidence demonstrating acceptable results with hypofractionated regimens, there remain many unanswered questions. The current status of hypofractionated radiation and future directions for research are discussed.

Keywords: Breast cancer, Hypofractionation, Radiation therapy, Toxicity, Radiobiology

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PII: S0960-9776(10)00058-5

doi:10.1016/j.breast.2010.03.004

The Breast
Volume 19, Issue 3 , Pages 168-171, June 2010

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