The Breast
Volume 19, Issue 6 , Pages 499-505, December 2010

Trends in incidence of ductal carcinoma in situ: The effect of a population-based screening programme

  • Ragnhild Sørum

      Affiliations

    • Cancer Registry of Norway, Department of Screening-based Research, Box 5313 Majorstuen, N-0304 Oslo, Norway
    • Corresponding Author InformationCorresponding author. Tel.: +47 22 45 13 00; fax: +47 22 45 13 70.
    • ,
  • Solveig Hofvind

      Affiliations

    • Cancer Registry of Norway, Department of Screening-based Research, Box 5313 Majorstuen, N-0304 Oslo, Norway
    • Oslo University College, Faculty of Health Sciences, Oslo, Norway
    • ,
  • Per Skaane

      Affiliations

    • Oslo University Hospital Ullevaal, Department of Radiology, University of Oslo, Oslo, Norway
    • ,
  • Tor Haldorsen

      Affiliations

    • Cancer Registry of Norway, Department of Screening-based Research, Box 5313 Majorstuen, N-0304 Oslo, Norway

Received 7 April 2010; received in revised form 21 May 2010; accepted 21 May 2010. published online 18 June 2010.

Abstract 

Background

The incidence of ductal carcinoma in situ (DCIS) has increased substantially in the western world in recent decades. The aim of this study was to investigate the incidence according to grade distribution, age, and implementation of a population-based screening programme.

Methods

Cases of primary pure DCIS (n = 3167) were obtained from the Cancer Registry of Norway. Poisson regression was used to estimate trends in incidence.

Results

Age-adjusted incidence of DCIS increased from 4 to 11 per 100 000 women-years from 1993 to 2007, in parallel with the implementation of screening. Higher incidence was observed among prevalent (IRR 3.3) and subsequent (IRR 2.8) invited women compared with those not invited. The proportion of DCIS among breast malignancies increased throughout the period, most markedly in the age range of screening.

Conclusion

The increased proportion of DCIS during the study period is probably due to improved diagnostics resulting from the implementation of population-based screening.

Keywords: Age, Ductal carcinoma in situ of the breast (DCIS), Epidemiology, Grade, Incidence rate, Screening

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PII: S0960-9776(10)00146-3

doi:10.1016/j.breast.2010.05.014

The Breast
Volume 19, Issue 6 , Pages 499-505, December 2010

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